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Hodgkin's disease and leukemia.

B W Chan, J A McBride

    Canadian Medical Association Journal
    |March 4, 1972
    PubMed
    Summary

    Acute myeloid leukemia can be a complication for long-term survivors of Hodgkin

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    Area of Science:

    • Hematology
    • Oncology

    Background:

    • Hodgkin's disease is a cancer of the lymphatic system.
    • Secondary malignancies can occur in cancer survivors.
    • The association between Hodgkin's disease and acute leukemia is rare but significant.

    Purpose of the Study:

    • To describe four cases of acute leukemia in patients with Hodgkin's disease.
    • To review the existing literature on this dual diagnosis.
    • To discuss the implications for long-term survivors and prognosis.

    Main Methods:

    • Case series presentation of four patients.
    • Comprehensive literature review on Hodgkin's disease and acute leukemia.
    • Brief discussion of Reed Sternberg cell cytology and cytochemistry.

    Main Results:

    • Acute myeloid or undifferentiated leukemias were observed.
    • These leukemias appear to be a complication in long-term Hodgkin's disease survivors.
    • Reed Sternberg cell leukemia, a variant of Hodgkin's, is associated with a poor prognosis.

    Conclusions:

    • Acute leukemia is a potential complication in Hodgkin's disease survivors.
    • Reed Sternberg cell leukemia indicates a grave prognosis.
    • Further understanding of the pathophysiology and management is warranted.

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