Related Experiment Video
Updated: Aug 16, 2026
18:48
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
Cell proliferation during immunological perturbation in three transplanted tumours
British Journal of Cancer
|April 1, 1972
Summary
Tumor growth can be halted by altering the host's immune system, without significantly changing cell division rates. This suggests immune modulation impacts tumor cell proliferation and survival.
Area of Science:
- Oncology
- Immunology
- Cell Biology
Background:
- Tumor growth is a complex process influenced by both intrinsic cancer cell characteristics and the host's immune system.
- Understanding how immune status affects tumor cell population kinetics is crucial for developing effective cancer therapies.
Purpose of the Study:
- To investigate the impact of altered host immunological status on the cell population kinetics of transplantable tumors.
- To determine if tumor growth arrest correlates with changes in cell cycle parameters.
Main Methods:
- Studied the cell population kinetics of three transplantable tumors in hosts with modified immunological status.
- Analyzed tumor growth rate, median intermitotic time, and cell loss rates.
Main Results:
- Tumor growth rate was modified by disturbing the host's immunological status.
- Complete growth arrest was achieved in two of the three tumors studied.
- A significant change in the median intermitotic time of proliferating cells was not observed despite growth arrest.
Conclusions:
- Tumor growth retardation and arrest can be achieved by modulating the host immune system.
- Growth modulation appears to be primarily due to a reduction in the proportion of actively proliferating cells and the rate of cell production, rather than a significant alteration in cell cycle duration.
- Cell loss rate may also contribute to growth retardation, with or without changes in proliferation.
