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Postinfective malabsorption: a sprue syndrome.

R D Montgomery, D J Beale, H G Sammons

British Medical Journal

|May 5, 1973

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Infective enteritis can cause temporary malabsorption in adults, presenting with diarrhea and weight loss. Most patients recover spontaneously, but some experience prolonged illness, resembling tropical sprue.

Area of Science:

Gastroenterology
Internal Medicine
Nutritional Science

Background:

Infective enteritis can lead to temporary malabsorption syndromes in adults.
Clinical presentation includes diarrhea, anorexia, and weight loss.

Purpose of the Study:

To describe the clinical features and outcomes of temporary malabsorption following infective enteritis.
To investigate the functional and morphological changes in the small bowel.

Main Methods:

Case series of thirteen adults with temporary malabsorption.
Clinical evaluation, including assessment of diarrhea, anorexia, and weight loss.
Investigation of small bowel function and morphology.

Main Results:

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Diffuse small bowel dysfunction, including the ileum, was observed.

Upper jejunal mucosa morphology was well-preserved.

Rapid folate depletion was a common finding.

Most cases showed spontaneous recovery within weeks, but two had prolonged, severe courses.

Conclusions:

The syndrome shares features with tropical sprue but may be influenced by nutritional and environmental factors.
A spectrum of severity exists, ranging from megaloblastic anemia to severe malabsorption.
Temporary malabsorption following enteritis is a recognized clinical entity with generally favorable outcomes.