Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adjuvant chemotherapy: theoretical considerations and model studies.

L M van Putten, J de Ruiter, C J van de Velde

    Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Multiscale X-ray scattering elucidates activation and deactivation of oxide-derived copper electrocatalysts for CO<sub>2</sub> reduction.

    Nature communications·2025
    Same author

    Anaesthesia for children with cancer.

    BJA education·2024
    Same author

    The novel Mechanical Ventilator Milano for the COVID-19 pandemic.

    Physics of fluids (Woodbury, N.Y. : 1994)·2021
    Same author

    Impact of resection margin status on recurrence and survival in pancreatic cancer surgery.

    The British journal of surgery·2019
    Same author

    Evaluation of applying IHC4 as a prognostic model in the translational study of Intergroup Exemestane Study (IES): PathIES.

    Breast cancer research and treatment·2017
    Same author

    A novel label-free cell-based assay technology using biolayer interferometry.

    Biosensors & bioelectronics·2016

    Many experimental tumors respond better to chemotherapy for minimal disease than for large tumors. However, some tumors show less response to minimal disease treatment, aligning with clinical observations.

    Area of Science:

    • Oncology
    • Pharmacology
    • Tumor Biology

    Background:

    • Adjuvant chemotherapy is used to treat minimal residual disease after primary tumor removal.
    • The efficacy of chemotherapy can vary significantly between minimal disease and large tumor burdens.
    • Clinical observations suggest a complex relationship between treatment response and tumor size.

    Purpose of the Study:

    • To compare the response of experimental minimal disease tumors to adjuvant chemotherapy with the response of large tumors to similar drug regimens.
    • To investigate whether the success of adjuvant chemotherapy for minimal disease can be predicted from its efficacy against manifest (large) tumors.

    Main Methods:

    • Utilized experimental tumor models to assess chemotherapy response.
    • Administered similar drug regimens to both minimal disease and large tumor experimental groups.

    Related Experiment Videos

  • Compared treatment outcomes between the two experimental conditions.

    • Main Results:

    • Many experimental tumors demonstrated greater responsiveness to chemotherapy when in a minimal disease state.
    • A subset of model tumors exhibited significantly lower response rates to chemotherapy in minimal disease conditions compared to large tumors.
    • The response patterns in these specific model tumors mirrored clinical observations.

    Conclusions:

    • The responsiveness of tumors to chemotherapy differs between minimal and manifest disease states.
    • The success of adjuvant chemotherapy for minimal disease cannot be reliably predicted from its efficacy against large tumors.
    • Clinical outcomes of adjuvant chemotherapy may be influenced by tumor-specific responses to minimal disease treatment.