Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Iproniazid-induced biochemical changes in mice.

R P Maickel, D R Bowman, N Fedynskyj

    Research Communications in Chemical Pathology and Pharmacology
    |July 1, 1979
    PubMed
    Summary

    Iproniazid affects blood glucose and liver fats differently based on diet and duration. Pyridoxine deficiency alters iproniazid

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correction: The role of ion solvation in lithium mediated nitrogen reduction.

    Journal of materials chemistry. A·2023
    Same author

    The role of ion solvation in lithium mediated nitrogen reduction.

    Journal of materials chemistry. A·2023
    Same author

    Contamination of domestic groundwater systems by verotoxigenic escherichia coli (VTEC), 2003-2019: A global scoping review.

    Water research·2020
    Same author

    Cryptosporidium spp. in groundwater supplies intended for human consumption - A descriptive review of global prevalence, risk factors and knowledge gaps.

    Water research·2020
    Same author

    Recent Work Concerning the Ætiology of Essential Hypertension.

    Glasgow medical journal·2018
    Same author

    One Hundred Consecutive Cases of Acute Lobar Pneumonia Treated with Sulphapyridine.

    Glasgow medical journal·2018

    Area of Science:

    • Biochemistry
    • Pharmacology
    • Animal Models

    Background:

    • Iproniazid is a monoamine oxidase inhibitor.
    • Dietary factors, such as pyridoxine, can influence drug metabolism and effects.
    • Understanding drug-induced metabolic changes is crucial for safety and efficacy.

    Purpose of the Study:

    • To investigate the effects of iproniazid on glucose and lipid metabolism in mice.
    • To determine the role of pyridoxine deficiency in modulating iproniazid's metabolic effects.
    • To examine the impact of chronic iproniazid administration on liver triglycerides.

    Main Methods:

    • Administration of single and multiple doses of iproniazid to Swiss-Webster mice.
    • Utilizing pyridoxine-deficient diets in conjunction with iproniazid treatment.
    • Measuring plasma glucose, free fatty acids (FFA), and liver triglycerides (TGL).
    • Comparing effects across different mouse strains (Swiss-Webster, C57/B1, DBA, AKR).

    Main Results:

    • Single iproniazid doses induced hypoglycemia and transient liver triglyceride changes in normal mice.
    • In pyridoxine-deficient mice, iproniazid elevated plasma glucose, FFA, and liver FFA/TGL.
    • Chronic iproniazid administration increased liver TGL in multiple strains, an effect reversed by pyridoxine deficiency, except in AKR mice.

    Conclusions:

    • Iproniazid's metabolic effects are significantly influenced by pyridoxine status.
    • Pyridoxine deficiency exacerbates certain adverse metabolic effects of iproniazid.
    • Strain-specific differences exist in the response to iproniazid, particularly concerning pyridoxine deficiency.

    Related Experiment Videos