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Protein binding properties of prazosin
Research Communications in Chemical Pathology and Pharmacology
|July 1, 1979
Summary
Prazosin exhibits high serum protein binding, approximately 92%, at therapeutic concentrations. This binding remains unaffected by other commonly co-administered drugs, indicating consistent pharmacokinetic behavior.
Area of Science:
- Pharmacology
- Biochemistry
Background:
- Prazosin is an alpha-adrenergic blocker used to treat hypertension.
- Understanding drug-protein binding is crucial for predicting drug efficacy and distribution.
Purpose of the Study:
- To determine the extent of serum protein binding for prazosin.
- To investigate the impact of co-administered drugs on prazosin's protein binding.
Main Methods:
- Equilibrium dialysis technique was employed.
- Radiolabeled prazosin with high specific activity was utilized.
Main Results:
- Prazosin demonstrates significant serum protein binding, approximately 92%, at therapeutic concentrations.
- Co-administration with other frequently used drugs did not alter prazosin's protein binding percentage.
Conclusions:
- Prazosin exhibits high and consistent protein binding in serum.
- The presence of other drugs does not significantly affect prazosin's protein binding profile.