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[Severe colitis with eosinophilia].
Schweizerische Medizinische Wochenschrift
|June 16, 1979
Summary
A patient with schistosomiasis developed severe, unclassifiable colitis with extreme eosinophilia. Colectomy provided temporary relief, but symptoms recurred, suggesting a novel, treatment-resistant condition.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Immunology
Background:
- Schistosomiasis is a parasitic disease affecting multiple organs.
- Persistent eosinophilia can indicate underlying inflammatory or allergic conditions.
Observation:
- A patient successfully treated for schistosomiasis developed severe, unclassifiable colitis with marked eosinophilia (>50,000/mm³).
- Endoscopic and histological findings were inconclusive, with massive eosinophilic infiltration of the colon.
Findings:
- Total colectomy led to remission of colitis and normalization of eosinophil counts.
- Recurrence of bleeding and eosinophilia occurred post-ileorectal anastomosis, indicating persistent disease activity.
Implications:
- This case highlights a potential novel clinical entity of unclassifiable colitis with eosinophilia post-schistosomiasis.
- The unresponsiveness to standard treatments and recurrence post-surgery warrant further investigation into the pathogenesis and differential diagnosis.