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Regional versus systemic heparinization.

C S Shin, A G Chaudhry, A Elizalde

    Surgery, Gynecology & Obstetrics
    |June 1, 1979
    PubMed
    Summary
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    Systemic and regional heparinization showed equal effectiveness in dogs. Regional heparin administration rapidly distributes throughout the circulation, indicating it functions as systemic heparinization, not truly regional.

    Area of Science:

    • Cardiovascular Surgery
    • Anesthesiology
    • Pharmacology

    Background:

    • Heparin is crucial for anticoagulation during vascular procedures.
    • The distinction between systemic and regional heparinization is important for managing bleeding risks and anticoagulation levels.

    Purpose of the Study:

    • To compare the effectiveness of systemic versus regional heparinization.
    • To determine if regional heparinization provides localized anticoagulation or distributes systemically.

    Main Methods:

    • 12 mongrel dogs were used.
    • Heparin (100 units/kg) was administered either systemically (intravenous) or regionally (intra-arterial).
    • Activated plasma thromboplastin time (aPTT) monitored heparin activity and blood coagulability in general and excluded circulations.

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    Main Results:

    • Both systemic and regional heparin administration were equally effective.
    • Heparin administered regionally rapidly distributed uniformly throughout both the excluded and general circulations.
    • No significant difference in blood coagulability was observed between the general and excluded circulations.

    Conclusions:

    • Regional heparinization, as administered in this study, is functionally equivalent to systemic heparinization.
    • The term 'regional heparinization' may be a misnomer, as the anticoagulant effect is not localized.