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Acute leukemic cells. Qualitative and quantitative electron microscopy.

H R Schumacher, I E Szekely, S A Park

    The American Journal of Pathology
    |October 1, 1973
    PubMed
    Summary
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    Electron microscopy revealed distinct quantitative and qualitative differences in acute leukemia cells. These ultrastructural findings in stem cell leukemia and other acute leukemias offer insights for further research.

    Area of Science:

    • Hematology
    • Cell Biology
    • Oncology

    Background:

    • Acute leukemias are heterogeneous hematologic malignancies.
    • Understanding cellular morphology is crucial for diagnosis and prognosis.

    Purpose of the Study:

    • To perform quantitative and qualitative electron microscopic analysis of various acute leukemia subtypes.
    • To identify ultrastructural differences and abnormalities in leukemic cells.

    Main Methods:

    • Electron microscopy (quantitative and qualitative) was used.
    • Studied leukemic cells from patients with stem cell leukemia, acute lymphoblastic leukemia, acute monoblastic leukemia, acute myeloblastic leukemia, and acute monomyeloblastic leukemia.

    Main Results:

    • Significant quantitative differences observed in heterochromatin:euchromatin ratios, cell size, granules, endoplasmic reticulum, and polyribosomes.

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  • Qualitative abnormalities noted across all groups, including nuclear pockets, indentations, disrupted mitochondria with virus-like particles, and myelin whorls.
  • Deranged carbohydrate metabolism suggested by smaller granules in disrupted mitochondria; virus-like particles in mitochondria require further investigation.

    • Conclusions:

    • Ultrastructural variations exist among different acute leukemia subtypes.
    • Specific findings like virus-like particles in mitochondria warrant further research.
    • Electron microscopy provides valuable clues for investigating acute leukemia cells.