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Tail anomaly lethal Tal: a new mutant gene in the rat
Teratology
|February 1, 1979
Summary
A novel hereditary tail anomaly, characterized by short, kinked tails in rats, was discovered. This autosomal dominant mutation,
Area of Science:
- Genetics
- Developmental Biology
- Teratology
Background:
- Teratological studies using trypan blue identified a new hereditary tail anomaly in rats.
- The anomaly presents as a short and kinked tail.
Purpose of the Study:
- To characterize a newly discovered hereditary tail anomaly in rats.
- To determine the genetic basis and embryonic lethality of this tail anomaly.
Main Methods:
- Teratological studies with trypan blue.
- Genetic analysis to determine inheritance patterns.
- Embryonic development observation.
Main Results:
- A new hereditary tail anomaly (gene symbol Tal) was identified in rats.
- Genetic analysis revealed an autosomal dominant mode of inheritance.
- Homozygous mutants exhibited prenatal lethality, with degeneration signs appearing in the late egg cylinder stage.
- The mutant phenotype resembles T-locus mutants in mice.
Conclusions:
- The hereditary tail anomaly in rats is controlled by an autosomal dominant gene (Tal).
- Homozygosity for the Tal gene results in embryonic lethality.
- This rat model may offer insights into T-locus gene functions in mammals.