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Biophysical and immunological studies on the differential effect of guanidine hydrochloride on type A and type B
The Journal of Hygiene
|February 1, 1974
Abstract:
Guanidine hydrochloride selectively inactivated both the biological activity and the immunogenicity of the haemagglutinin of influenza A/X-7 (HON2). The residual neuraminidase was fully active biologically and immunologically. The reverse was observed with influenza B/ROB; with this virus the haemagglutinin was resistant, and was immunogenic; while the neuraminidase was selectively inactivated, and was not immunogenic.