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Auditory double click evoked potentials in multiple sclerosis.

F Mogensen, O Kristensen

    Acta Neurologica Scandinavica
    |March 1, 1979
    PubMed
    Summary
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    Brain stem electric responses (BSER) showed abnormalities in 83% of multiple sclerosis patients. The FFP7 component was the most consistently abnormal, aiding in diagnosis despite no clear link to clinical symptoms.

    Area of Science:

    • Neuroscience
    • Audiology
    • Clinical Neurology

    Background:

    • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
    • Brain stem auditory evoked potentials (BAEPs) are sensitive to brain stem pathway integrity.
    • Previous studies suggest BAEP abnormalities in MS, but specific component analysis requires further investigation.

    Purpose of the Study:

    • To investigate brain stem electric responses (BSER) in multiple sclerosis (MS) patients.
    • To identify the most reliable BSER components for detecting abnormalities in MS.
    • To correlate BSER findings with clinical signs of brain stem dysfunction.

    Main Methods:

    • BSER were recorded in 29 MS patients and 26 healthy controls using monaural and binaural acoustic stimuli.

    Related Experiment Videos

  • Evaluated components included Jewett I, III, V, and the FFP7 peak.
  • Latency and interpeak conduction times were analyzed.

    • Main Results:

    • The FFP7 component demonstrated high reproducibility in normal subjects and was the most consistently abnormal in MS patients.
    • 83% (20 out of 24) of MS patients without hearing impairment showed BSER abnormalities.
    • Abnormalities were detected through component latency, interpeak times, and FFP7 analysis.

    Conclusions:

    • BSER, particularly the FFP7 component and latency/interpeak measures, are valuable for detecting brain stem dysfunction in MS.
    • A high prevalence of BSER abnormalities was observed in MS patients.
    • No clear correlation was found between BSER abnormalities and clinical brain stem signs in this cohort.