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Lesions experimentally produced by fungi implicated in extrinsic allergic alveolitis
The Journal of Hygiene
|December 1, 1974
Abstract:
The ability of Aureobasidium pullulans, Cladosporium herbarum and Cryptostroma corticale to produce local lesions in the rabbit was examined. Both C. corticale and A. pullulans can survive in vivo and produce the inflammatory response typical of mycetoma. C. herbarum failed to grow or survive in vivo.
Insights
Cryptostroma corticale and Aureobasidium pullulans can survive in vivo, causing inflammation typical of mycetoma. Cladosporium herbarum did not grow or survive in vivo.
Area of Science:
- Medical Mycology
- Pathogen Discovery
Background:
- Fungi are increasingly recognized as significant human pathogens.
- Understanding fungal virulence factors is crucial for developing effective treatments.
Purpose of the Study:
- To evaluate the pathogenic potential of Aureobasidium pullulans, Cladosporium herbarum, and Cryptostroma corticale in a rabbit model.
- To determine the in vivo survival and inflammatory response of these fungi.
Main Methods:
- Intradermal inoculation of rabbits with A. pullulans, C. herbarum, and C. corticale.
- Assessment of lesion development and fungal viability in vivo.
Main Results:
- Cryptostroma corticale and Aureobasidium pullulans demonstrated in vivo survival and induced inflammatory responses consistent with mycetoma.
- Cladosporium herbarum was unable to survive or proliferate within the host tissues.
Conclusions:
- A. pullulans and C. corticale possess the ability to cause localized infections and inflammatory reactions in mammals.
- C. herbarum exhibits limited pathogenic potential in this experimental model.