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Endotoxin shock in the beagle dog.
American Journal of Obstetrics and Gynecology
|May 15, 1979
Summary
Endotoxemia caused severe hemodynamic and metabolic issues in dogs, but low-molecular weight dextran (LMDX) therapy reversed these effects, restoring normal function and resolving acidosis.
Area of Science:
- Veterinary Medicine
- Cardiovascular Physiology
- Sepsis Research
Background:
- Endotoxemia, a condition caused by bacterial endotoxins, leads to significant physiological disturbances.
- Understanding the hemodynamic and metabolic consequences of endotoxemia is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the effects of endotoxemia on cardiovascular and metabolic parameters in conscious dogs.
- To evaluate the efficacy of low-molecular weight dextran (LMDX) in reversing endotoxemia-induced shock.
Main Methods:
- Seven splenectomized beagle dogs were instrumented to measure cardiac output, pressures, and heart rate.
- Arterial blood gases, pH, lactate, and pyruvate were analyzed before and after endotoxin administration and LMDX treatment.
- Endotoxin (1 mg/kg) was administered intravenously, followed by LMDX (2 ml/kg/min for 15 minutes) after two hours.
Main Results:
- Endotoxin induced a sharp decline in cardiac output, heart rate, and systemic arterial pressure, accompanied by pulmonary hypertension and increased vascular resistance.
- Metabolic acidosis with excess lactate accumulation was observed.
- LMDX treatment significantly improved cardiac output, systemic arterial pressure, and pulmonary arterial pressure, while resolving metabolic acidosis and oxygen debt.
Conclusions:
- Pulmonary and systemic vasoconstriction were not persistent in endotoxemic shock.
- The cardiovascular response to endotoxin in both pulmonary and systemic vascular beds was similar.
- Oncotic fluid therapy with LMDX effectively restored hemodynamic and metabolic parameters to pre-shock levels.