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Hyponeophagia: A Measure of Anxiety in the Mouse
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Hyperphagia in intestinal disease.

R J Hall, B Creamer

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    Summary
    This summary is machine-generated.

    Severe malabsorption and steatorrhoea in six patients were linked to hyperphagia (excessive calorie intake). Depression was also noted in some. Dietary assessment and caloric restriction can help manage these conditions.

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    Area of Science:

    • Gastroenterology
    • Internal Medicine
    • Clinical Nutrition

    Background:

    • Hyperphagia, characterized by excessive caloric intake (5,000-11,000 Kcals/day), can be associated with severe malabsorption and steatorrhoea.
    • The underlying causes of malabsorption in affected individuals can vary, including celiac disease, Crohn's disease with ileal resection, and pancreatic carcinoma.

    Purpose of the Study:

    • To describe six patients with hyperphagia, severe malabsorption, and steatorrhoea.
    • To investigate potential contributing factors, including neurological, endocrine, and psychological conditions.
    • To explore the therapeutic implications of dietary management in such cases.

    Main Methods:

    • Case series description of six patients presenting with hyperphagia, malabsorption, and steatorrhoea.
    • Assessment for neurological and endocrine disorders.
    • Evaluation of psychological status, specifically depression.
    • Dietary assessment focusing on caloric and fat intake.

    Main Results:

    • Three patients had coeliac disease, two had Crohn's disease with ileal resection, and one had pancreatic carcinoma.
    • Three patients experienced severe depression, suggesting a potential common association.
    • Caloric and fat intake restriction led to decreased steatorrhoea without weight loss in several patients.

    Conclusions:

    • Hyperphagia associated with severe malabsorption and steatorrhoea can occur with various gastrointestinal and oncological conditions.
    • Severe depression may be more commonly associated with these conditions than previously recognized.
    • Dietary interventions, including caloric and fat restriction, show therapeutic potential for managing steatorrhoea in these patients.