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Related Experiment Videos

[Pathologic neutrophilia in acute leukemia].

A Anatkov, A Dobreva, K Noev

    Vutreshni Bolesti
    |January 1, 1974
    PubMed
    Summary

    This study identifies unique "paraneutrophils" in acute leukosis patients, distinct from normal cells. These cells have significant prognostic value and resist chemotherapy, indicating a specific leukosis variant.

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    [Ultrastructural and aggregation studies of the thrombocytes during cytopheresis].

    Eksperimentalna meditsina i morfologiia·1988

    Area of Science:

    • Hematology
    • Oncology
    • Cell Biology

    Context:

    • Acute leukosis diagnosis can be challenging, with atypical cell morphology sometimes observed.
    • Understanding variations in leukemic cell presentation is crucial for accurate prognosis and treatment.
    • The presence of unusual cell types in peripheral blood requires detailed characterization.

    Purpose:

    • To describe the morphological and cytochemical peculiarities of atypical neutrophils in patients with acute leukosis.
    • To investigate the nature of these
    • paraneutrophils
    • using cytomorphologic, cytochemical, and electron microscopic methods.
    • To determine the clinical and prognostic significance of these cells in acute leukosis.

    Summary:

    • Morphological hemogram analysis of 10 acute leukosis patients revealed the presence of granular "filamented neutrophils" (paraneutrophils) in peripheral blood.
    • Cytomorphologic, cytochemical, and electron microscopic studies confirmed these paraneutrophils possess pathological leukosis characteristics, differentiating them from normal neutrophils.
    • Histomorphological investigation in five patients excluded a primary myeloblast phase, supporting a distinct leukosis variant.

    Impact:

    • Identified
    • paraneutrophils
    • as cells with significant prognostic value in peripheral blood, comparable to paramyeloblasts.
    • Demonstrated that these paraneutrophils are unaffected by polychemical therapy, suggesting therapeutic resistance.
    • Highlights a particular variance of acute leukosis requiring specific diagnostic and potentially therapeutic considerations.

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