Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left ventricular function and compliance in swine during halothane anesthesia.

R W Brower, R G Merin

    Anesthesiology
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Acute oliguria.

    The New England journal of medicine·1998
    Same author

    Anesthesiology.

    The New England journal of medicine·1998
    Same author

    New directions in the treatment of heart failure: some paradoxical observations.

    Journal of cardiac surgery·1995
    Same author

    Does isoflurane produce coronary vasoconstriction?

    Anesthesiology·1994
    Same author

    Myocardial "stunning" and substrate metabolism.

    Journal of cardiac surgery·1994
    Same author

    Why is the laser-guard protective coating better than the foil tapes?

    Anesthesia and analgesia·1994
    Same journal

    The Time-out.

    Anesthesiology·2026
    Same journal

    Evaluation of Post-block Hypersensitivity Using Quantitative Sensory Testing Before, During, and After Axillary Brachial Plexus Block Resolution in Healthy Volunteers.

    Anesthesiology·2026
    Same journal

    The state of medical education research in Anesthesiology: Current landscape and future directions - An initiative of the Anesthesia Research Council.

    Anesthesiology·2026
    Same journal

    Diagnostic Ultrasound-guided Focused Ultrasound-induced Noninvasive, Reversible Peripheral Nerve Blockade in an In Vivo Model of Acute Pain: A Proof-of-Concept Study.

    Anesthesiology·2026
    Same journal

    S-Ketamine Reduces Risk of Postoperative Delirium: Comment.

    Anesthesiology·2026
    Same journal

    Computed Tomography-Based Body Composition Assessment for Preoperative Cardiovascular Risk Prediction: A Prospective Cohort Study.

    Anesthesiology·2026
    See all related articles

    Halothane anesthesia in pigs significantly depresses cardiac function in a dose-dependent manner, reducing blood pressure and cardiac output. However, it did not alter ventricular pressure-volume relationships, indicating preserved cardiac compliance.

    Area of Science:

    • Cardiology
    • Anesthesiology
    • Physiology

    Background:

    • Halothane is a widely used inhalational anesthetic.
    • Understanding its effects on cardiac function is crucial for patient safety.
    • Pigs are often used as a model for human cardiovascular research.

    Purpose of the Study:

    • To investigate the dose-dependent effects of halothane on ventricular function in pigs.
    • To assess the impact of halothane on cardiac output, left ventricular pressure, and contractility.
    • To determine if halothane affects ventricular pressure-volume relationships (cardiac compliance).

    Main Methods:

    • Anesthesia was induced using halothane in nitrous oxide and oxygen in closed-chest pigs.
    • Cardiac output was measured using thermodilution.

    Related Experiment Videos

  • Left ventricular (LV) pressure indices, volumes, and compliance were assessed via LV angiography.
  • Control experiments confirmed minimal effects of nitrous oxide, time, and dye injections.

    • Main Results:

    • Halothane caused dose-dependent reductions in aortic blood pressure, cardiac output, LV dP/dt, Vmax, and ejection fraction.
    • Heart rate and circumferential fiber shortening rate decreased, but not in a dose-dependent manner.
    • A significant negative inotropic effect of halothane was observed.
    • No clear effect on ventricular pressure-volume relationships (compliance) was detected, likely obscured by cardiac depression.

    Conclusions:

    • Halothane exerts a potent, dose-related negative inotropic effect on the pig heart.
    • Despite cardiac depression, halothane did not significantly alter ventricular compliance in this model.
    • These findings highlight the dose-dependent cardiovascular depressant effects of halothane.