Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Colitis and pseudomembranous colitis associated with cephazolin prophylaxis.

T J Degan, H J Fee, M E Ament

    The American Surgeon
    |June 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Metabolism of zinc-binding ligands in rat small intestine.

    Biological trace element research·2013
    Same author

    Levels and distribution of zinc, copper, magnesium, and calcium in rats fed different levels of dietary zinc.

    Biological trace element research·2013
    Same author

    Pediatric health-related quality of life after intestinal transplantation.

    Pediatric transplantation·2011
    Same author

    Structure and function of the gastrointestinal tract in primary immunodeficiency syndromes. A study of 39 patients.

    Medicine·2010
    Same author

    Body weight reduction in rats by oral treatment with zinc plus cyclo-(His-Pro).

    British journal of pharmacology·2009
    Same author

    Rejection and steroid dependence: unique risk factors in the development of pediatric posttransplant de novo autoimmune hepatitis.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2007

    Cephalexin therapy can cause colitis, a serious condition characterized by severe diarrhea. Promptly stopping the antibiotic and providing supportive care can lead to patient survival.

    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Internal Medicine

    Background:

    • Cephalexin, a common antibiotic, has been rarely associated with gastrointestinal side effects.
    • Colitis, an inflammation of the colon, can manifest with severe symptoms and requires prompt diagnosis and management.

    Observation:

    • Three surgically treated patients with complex medical histories developed severe diarrhea, abdominal pain, fever, and leukocytosis during cephalexin therapy.
    • Stool cultures were negative, and one patient presented with a pseudomembrane, indicative of C. difficile infection, though this was not confirmed in all cases.

    Findings:

    • Discontinuation of cephalexin, coupled with bowel rest and intravenous hydration, resulted in the recovery of all three patients.
    • The clinical presentation, including profuse diarrhea and negative stool cultures, strongly suggested antibiotic-associated colitis.

    Related Experiment Videos

    Implications:

    • This case series highlights the importance of considering cephalexin-induced colitis in patients presenting with severe diarrhea during antibiotic treatment.
    • Early recognition and intervention are crucial for favorable outcomes in antibiotic-associated colitis.
    • Further research may elucidate the precise mechanisms and incidence of cephalexin-associated colitis.