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Related Experiment Videos

Allergic hypersensitivity to neomycin. Relationship between patch test reactions and 'use' tests.

S D Prystowsky, J H Nonomura, R W Smith

    Archives of Dermatology
    |June 1, 1979
    PubMed
    Summary
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    Neomycin patch test sensitivity affects about 1% of people. Clinical use tests showed that positive patch tests often correlate with reactions to neomycin-containing antibiotic creams and ointments.

    Area of Science:

    • Dermatology
    • Allergy and Immunology
    • Pharmacology

    Background:

    • Neomycin patch test sensitivity affects approximately 1% of the general population.
    • Understanding the clinical relevance of positive neomycin patch tests is crucial for patient care.

    Purpose of the Study:

    • To investigate the relationship between positive neomycin patch tests and clinical reactions to neomycin-containing antibiotic preparations.
    • To evaluate the utility of clinical use tests in assessing neomycin hypersensitivity.

    Main Methods:

    • Subjects with positive neomycin patch tests underwent clinical use tests using Neosporin G cream and Neosporin ointment.
    • Reactions were assessed based on positivity, timing, and intensity of the response.

    Main Results:

    Related Experiment Videos

    • Positive use tests were observed in 7/8 subjects with strongly positive patch tests and 2/4 with weakly positive patch tests.
    • Reactions were typically faster and more intense with the cream base compared to the ointment.
    • Most use test reactions were mild, even with continued exposure.

    Conclusions:

    • Clinical use tests with commercial neomycin products can help determine the real-world significance of positive patch tests.
    • The findings support the use of patch testing and subsequent use testing for diagnosing neomycin hypersensitivity.