Unilateral, linear, zosteriform epidermal nevus with acantholytic dyskeratosis

Area of Science:

• Dermatology
• Histopathology
• Genetic Dermatology

Background:

• Nevus unius lateris is a rare congenital condition.
• Unilateral Darier's disease has been a historical classification for similar cases.
• Acantholytic dyskeratosis is the observed histopathologic finding.

Observation:

• The study presents a case of nevus unius lateris in an infant.
• The infant's condition exhibited histopathologic features of acantholytic dyskeratosis.
• Previous classifications grouped such cases under unilateral Darier's disease.

Findings:

• Acantholytic dyskeratosis is not a specific indicator of a single disease entity.
• The histopathologic findings in this case challenge existing diagnostic criteria.
• The specificity of pathological changes requires further investigation.

Implications:

• The concept of unilateral keratosis follicularis warrants reevaluation.
• This case suggests a need for revised diagnostic approaches for rare dermatological conditions.
• Further research is needed to differentiate conditions presenting with acantholytic dyskeratosis.