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Related Experiment Videos

The second international standard for chlortetracycline.

J W Lightbown, J M Bond, M V Mussett

    Bulletin of the World Health Organization
    |January 1, 1972
    PubMed
    Summary

    A new International Standard for Chlortetracycline was established through a global collaborative assay. Its potency aligns with the previous standard, ensuring continued accurate measurement of this vital antibiotic.

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    Area of Science:

    • Pharmacology and Pharmaceutical Sciences
    • Microbiology
    • Analytical Chemistry

    Background:

    • The International Standard for Chlortetracycline (CTC) was nearing depletion.
    • A replacement standard was necessary to maintain consistent potency measurements.

    Purpose of the Study:

    • To establish and define the potency of a second International Standard for Chlortetracycline.
    • To ensure the new standard's International Units (IU) were comparable to the first standard.

    Main Methods:

    • An international collaborative assay involving 157 individual assays across 9 laboratories in 6 countries.
    • Statistical analysis of potency data from participating laboratories.

    Main Results:

    • The mean potencies across laboratories showed a 7% variation but were statistically heterogeneous.

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  • The overall mean potency of the second standard did not significantly differ from the first International Standard.
  • The International Unit for chlortetracycline was defined as 1000 IU/mg based on the second standard.

    • Conclusions:

    • The second International Standard for Chlortetracycline is a reliable replacement for the first.
    • The established potency ensures continued accurate quantification of chlortetracycline globally.