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Long-term selenium exposure.

C J Diskin, C L Tomasso, J C Alper

Archives of Internal Medicine

|July 1, 1979

Summary

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Long-term selenium exposure affects different organs in humans and animals. In humans, the lungs are the target organ, unlike the liver in animals, suggesting a need for revised monitoring.

Area of Science:

Toxicology
Environmental Health
Human Physiology

Background:

Understanding the toxic effects of long-term selenium exposure is crucial for occupational health and public safety.
Animal models are often used to predict human responses to environmental toxins, but species-specific differences can be significant.

Observation:

In animal models, chronic selenium exposure primarily targets the liver, leading to cirrhosis.
Human cases of chronic selenium exposure present with distinct target organ toxicity, primarily affecting the lungs.

Findings:

The study identified the lung as the primary target organ in humans exposed to selenium long-term, contrasting with liver toxicity observed in animal models.
Selenium metabolism in humans favors the production of dimethylselenide, a volatile compound excreted via the lungs, indicating its role as a pulmonary toxin.

Related Experiment Videos

Tissue distribution of selenium differs between humans and animal models, influencing organ-specific toxicity.

Implications:

Findings necessitate a re-evaluation of monitoring techniques for industrial selenium exposure, focusing on pulmonary health.
The study highlights the need for caution regarding selenium's use as a health supplement due to potential pulmonary toxicity.
Further research into selenium's metabolic pathways and toxicological effects in humans is warranted.