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Simple method for detection of infection of peritoneum during dialysis
British Medical Journal
|June 2, 1973
Abstract:
The lysozyme (muramidase) content of peritoneal fluid samples has been found to be an early indicator of the onset of infection in the course of peritoneal dialysis. A level of 10.0 mug/ml indicates peritoneal infection and one of 7.5 mug/ml is highly suspicious.
Insights
Lysozyme (muramidase) in peritoneal fluid signals early infection during dialysis. Levels of 10.0 mug/ml confirm infection, while 7.5 mug/ml suggests a high risk, aiding timely diagnosis.
Area of Science:
- Biochemistry
- Nephrology
- Infectious Diseases
Background:
- Peritoneal dialysis (PD) is a crucial treatment for end-stage renal disease.
- Peritonitis, a serious complication of PD, requires early detection and treatment.
- Lysozyme (muramidase) is an enzyme with antimicrobial properties.
Purpose of the Study:
- To evaluate the diagnostic utility of lysozyme levels in peritoneal fluid for detecting PD-related infections.
- To establish threshold values for identifying peritoneal infection and suspicion.
Main Methods:
- Analysis of lysozyme concentrations in peritoneal fluid samples from PD patients.
- Correlation of lysozyme levels with clinical diagnosis of peritonitis.
Main Results:
- Lysozyme levels of 10.0 mug/ml were indicative of peritoneal infection.
- Lysozyme levels of 7.5 mug/ml were considered highly suspicious for infection.
- Elevated lysozyme demonstrates potential as an early biomarker.
Conclusions:
- Lysozyme concentration in peritoneal fluid is a valuable early indicator of infection in PD patients.
- Specific thresholds can aid in the prompt diagnosis and management of peritonitis.
- Monitoring lysozyme may improve patient outcomes in peritoneal dialysis.