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Published on: January 29, 2018
Peripheral electrophysiological parameters in mice treated with misonidazole
British Journal of Cancer
|July 1, 1979
Summary
Misonidazole, a radiosensitizer, did not affect nerve conduction velocity in mice. However, it caused a significant drop in body temperature, potentially protecting against neurotoxicity.
Area of Science:
- Neuroscience
- Pharmacology
- Radiotherapy
Background:
- Clinical use of misonidazole is limited by peripheral neuropathy.
- Previous studies suggested misonidazole reduces nerve conduction velocity.
Purpose of the Study:
- To investigate the neurotoxic effects of misonidazole on nerve electrophysiology.
- To determine if misonidazole affects nerve conduction velocity in mice.
Main Methods:
- In situ and isolated nerve electrophysiological measurements in mice.
- Assessed nerve conduction velocity, threshold, strength-duration curves, and refractory time.
- Monitored body temperature and misonidazole serum levels.
Main Results:
- Misonidazole did not alter nerve conduction velocity or other electrophysiological parameters.
- A single dose of misonidazole caused a significant decrease in body temperature.
- This hypothermic effect persisted for at least 2 hours post-administration.
Conclusions:
- Misonidazole does not appear to cause acute neurotoxicity affecting nerve conduction velocity in mice.
- The observed hypothermia may be a protective mechanism against misonidazole-induced neurotoxicity.
