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An International Reference Preparation for human serum immunoglobulin E.

D S Rowe, B Grab, S G Anderson

    Bulletin of the World Health Organization
    |January 1, 1973
    PubMed
    Summary

    An International Reference Preparation for Human Serum Immunoglobulin E was established. This provides standardized international units for accurate measurement of immunoglobulin E levels.

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    Area of Science:

    • Immunology
    • Biotechnology
    • Clinical Chemistry

    Background:

    • Accurate quantification of Human Serum Immunoglobulin E (IgE) is crucial for diagnosing allergic diseases and monitoring therapeutic responses.
    • Variability in IgE measurement across different laboratories necessitates the establishment of international standards.

    Purpose of the Study:

    • To establish an International Reference Preparation for Human Serum Immunoglobulin E.
    • To assign international units to this reference preparation for global standardization.

    Main Methods:

    • A collaborative assay involving five laboratories across four countries was conducted.
    • Standardization protocols were applied to ensure consistency in the assay.

    Main Results:

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    • An International Reference Preparation for Human Serum Immunoglobulin E has been successfully established.
    • International units have been assigned to the reference preparation.

    Conclusions:

    • The established reference preparation will enhance the accuracy and comparability of Human Serum Immunoglobulin E measurements worldwide.
    • This standardization is vital for consistent clinical diagnosis and research in allergy and immunology.