Related Experiment Video
Updated: Aug 11, 2026
11:15
Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
Published on: September 1, 2018
Humoral immunosuppressive substance in mice bearing plasmacytomas
Science (New York, N.Y.)
|November 22, 1974
Summary
Plasmacytomas (PC) suppress immune responses. Normal spleen cells in PC-bearing mice showed poor antibody production, suggesting a humoral factor mediates this immune suppression.
Area of Science:
- Immunology
- Oncology
Background:
- Plasmacytomas (PC) are known to impair the primary immune response.
- The specific mechanism of this immune depression remains unclear.
Purpose of the Study:
- To investigate the mechanism of immune suppression induced by plasmacytomas.
- To determine if plasmacytomas release a factor that inhibits immune cell function.
Main Methods:
- Normal spleen cells were enclosed in Millipore chambers.
- These chambers were implanted into mice bearing plasmacytomas.
- Antibody production by spleen cells was assessed after exposure to sheep red blood cells.
- Control groups included chambers implanted in normal mice and mice with other tumors.
Main Results:
- Spleen cells in chambers within PC-bearing mice exhibited a significantly reduced antibody response to sheep red blood cells.
- This suppressed response was more pronounced compared to spleen cells in chambers implanted in normal mice or mice with other tumor types.
Conclusions:
- Plasmacytoma-induced immune suppression is likely mediated by a soluble (humoral) factor.
- This factor circulates and affects the function of normal immune cells.
