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Activation of Epstein-Barr virus by 5-bromodeoxyuridine in "virus-free" human cells (complement-fixing
Abstract:
Treatment of three human lymphoid cell lines, free of detectable Epstein-Barr virus, with 5-bromodeoxyuridine resulted in activation of virus synthesis in up to 8% of the cells. The induction of infectious virus could be demonstrated by cocultivation experiments with peripheral leukocytes. These studies demonstrated that the entire viral genome may persist in at least a portion of the lymphoid cells.