Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bumetanide: potent new "loop" diuretic.

M J Asbury, P B Gatenby, S O'Sullivan

    British Medical Journal
    |January 22, 1972
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    250 cases of "type 2 Gaucher disease": A novel system of clinical categorisation and evidence of genotype: Phenotype correlation.

    Molecular genetics and metabolism·2025
    Same author

    Irish national real-world analysis of the clinical and economic impact of 21-gene oncotype DX® testing in early-stage, 1-3 lymph node-positive, oestrogen receptor-positive, HER2-negative, breast cancer.

    Breast cancer research and treatment·2024
    Same author

    The effect of manually facilitated flexion of the thoracic spine on the interspinous space among horses with impinging dorsal spinous processes of the thoracic vertebrae.

    Veterinary journal (London, England : 1997)·2022
    Same author

    Editorial: Mechanisms guarding the genome.

    Frontiers in cell and developmental biology·2022
    Same author

    Leave events among Aboriginal and Torres Strait Islander people: a systematic review.

    BMC public health·2022
    Same author

    Explainable artificial intelligence (XAI): closing the gap between image analysis and navigation in complex invasive diagnostic procedures.

    World journal of urology·2022
    Same journal

    Muscular pain during therapy with carbenoxolone (Biogastrone).

    British medical journal·2016
    Same journal

    ACUTE INTESTINAL OBSTRUCTION DUE TO INTRA-ABDOMINAL CAUSES.

    British medical journal·2014
    Same journal

    A CASE OF HAEMATIDROSIS.

    British medical journal·2014
    Same journal

    Incidence of ulcer in haematemesis.

    British medical journal·2011
    Same journal

    Pituitary hypothyroidism with impaired renal function.

    British medical journal·2011
    Same journal

    The fenestration operation for otosclerosis.

    British medical journal·2011
    See all related articles

    Bumetanide is a new diuretic that acts quickly and lasts for hours. It is as effective as frusemide but at a much lower dose, with minimal side effects in patients.

    Area of Science:

    • Pharmacology
    • Clinical Medicine
    • Diuretic Therapy

    Background:

    • Bumetanide represents a novel pharmacological agent in diuretic treatment.
    • Edematous conditions necessitate effective and safe diuretic interventions.

    Purpose of the Study:

    • To evaluate the pharmacokinetic and pharmacodynamic properties of bumetanide.
    • To compare the efficacy and safety of bumetanide with frusemide in edematous patients.

    Main Methods:

    • Pharmacokinetic analysis of bumetanide's onset, peak, and duration of action.
    • Controlled clinical study comparing bumetanide and frusemide in edematous patients.
    • Assessment of electrolyte excretion patterns and biochemical/hematological status during continuous bumetanide administration.

    Related Experiment Videos

    Main Results:

    • Bumetanide demonstrated rapid onset (within 30 minutes) and prolonged action (approx. 270 minutes).
    • Equipotent to frusemide at 1/40th molar dosage, with similar electrolyte excretion profiles.
    • Eight-day continuous oral administration resulted in effective diuresis with minimal biochemical and hematological changes.

    Conclusions:

    • Bumetanide is a potent and effective diuretic with a favorable pharmacokinetic profile.
    • Bumetanide offers comparable efficacy to frusemide at significantly lower doses.
    • The drug is well-tolerated, with only minor gastric discomfort reported as an adverse effect.