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Hexokinase of the adult dog heartworm, Dirofilaria immitis
W F Hutchison1, A C Turner, F J Oelshlegel
1Department of Preventive Medicine, University of Mississippi School of Medicine, Jackson 39216.
Abstract:
1. Dirofilaria immitis hexokinase was relatively heat stable and had a pH optimum range between 7.8 and 8.2. 2. Mean Vmax was 0.40 +/- 0.10 (S.D.) mumole/min/100 mg of worm. 3. Mean Km values were 0.32 mM for glucose, 0.86 mM for fructose and 0.39 mM for ATP. 4. Glucose-6-phosphate was not a strong product inhibitor. 5. Starch gel electrophoresis demonstrated at least three isozymes.