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NAD-linked glutamate dehydrogenase in Trypanosoma cruzi
J J Cazzulo1, B M de Cazzulo, A I Higa
1Centro de Estudios Fotosintéticos y Bioquímicos, Rosario, Argentina.
Abstract:
1. Epimastigotes of Trypanosoma cruzi, Tulahuén strain, contained a NAD-linked glutamate dehydrogenase (EC 1.4.1.3), in addition to the already known NADP-linked enzyme enzyme (EC 1.4.1.4). 2. The partially purified NAD-linked enzyme had a higher molecular weight and was much more labile than the NADP-linked enzyme, and was inhibited by purine nucleotides. 3. These results further emphasize the difference in glutamate metabolism between the parasite and its mammalian host.