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Vindesine as a single agent in the treatment of advanced malignant melanoma

S Retsas, K A Newton, G Westbury

    Cancer Chemotherapy and Pharmacology
    |January 1, 1979
    PubMed

    Insights

    Vindesine, a vinca alkaloid, showed a 30% objective response rate in patients with disseminated malignant melanoma. This study highlights vindesine

    Area of Science:

    • Oncology
    • Pharmacology

    Background:

    • Malignant melanoma is a significant health concern.
    • Vinca alkaloids are established chemotherapy agents.

    Purpose of the Study:

    • To evaluate the antitumour efficacy of vindesine in disseminated malignant melanoma.
    • To assess the response rate and side effects of vindesine therapy.

    Main Methods:

    • A phase-II clinical study was conducted.
    • Twenty-five patients with disseminated malignant melanoma were treated with vindesine.
    • Twenty-three patients were evaluable for response.

    Main Results:

    • Seven out of 23 evaluable patients (30%) demonstrated an objective response.
    • A notable response was observed in malignant effusions.
    • Common side effects were consistent with other vinca alkaloids, with potentially increased alopecia.

    Conclusions:

    • Vindesine demonstrates antitumour activity in disseminated malignant melanoma.
    • The drug is a potential treatment option, particularly for malignant effusions.
    • Vindesine shares side effect profiles with other vinca alkaloids.

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