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Banded structures in human nucleus pulposus.

J A Buckwalter, J A Maynard, R R Cooper

    Clinical Orthopaedics and Related Research
    |March 1, 1979
    PubMed
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    Unusual banded structures were found in the nucleus pulposus of all studied intervertebral disks. These structures may represent a novel collagen form or a response to mechanical stress.

    Area of Science:

    • Spinal Anatomy
    • Biochemistry
    • Electron Microscopy

    Background:

    • Intervertebral disks are crucial for spinal function.
    • Pathologies like scoliosis and disc herniation affect disk integrity.
    • The composition of the nucleus pulposus is not fully understood.

    Purpose of the Study:

    • To investigate the ultrastructure of human intervertebral disks.
    • To identify novel components within the nucleus pulposus.
    • To compare disk tissue from healthy and pathological conditions.

    Main Methods:

    • Electron microscopy was used to examine 20 intervertebral disks.
    • Tissue samples were obtained from patients with scoliosis, disc herniation, and autopsies.
    • Analysis focused on the nucleus pulposus and annulus fibrosus.

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    Main Results:

    • Distinct banded structures, different from native collagen, were observed in the nucleus pulposus of all samples.
    • These structures were absent in the annulus fibrosus.
    • The observed structures bore resemblance to extracellular filaments in frog muscle spindles.

    Conclusions:

    • The nucleus pulposus contains unique banded structures.
    • These structures might be an unusual collagen variant or a response to mechanical elongation.
    • Further research is needed to elucidate their exact nature and function.