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Related Experiment Videos

Spermatozoa repellent as a contraceptive.

W W Tso, W M Lee, M Y Wong

    Contraception
    |March 1, 1979
    PubMed
    Summary

    P-nitrophenyl-glycerol (PNPG) repels rat spermatozoa, inhibiting their movement. This discovery suggests potential for PNPG as a novel contraceptive agent by interfering with sperm motility.

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    Area of Science:

    • Biochemistry
    • Reproductive Biology
    • Microbiology

    Background:

    • P-nitrophenyl-glycerol (PNPG) previously identified as an antiswarming agent in Proteus.
    • Antiswarming activity may involve interference with negative chemotaxis.

    Purpose of the Study:

    • To investigate the effect of PNPG on rat epididymal spermatozoa motility.
    • To explore the potential of PNPG as a contraceptive agent.

    Main Methods:

    • Inverted capillary assay used to assess sperm motility response to chemical gradients.
    • Spermatozoa exposed to various suspending conditions, including PNPG gradients.

    Main Results:

    • PNPG exhibited an inhibitory effect on sperm motility at concentrations above 10(-5) M.
    • Significantly fewer spermatozoa migrated into PNPG gradients, indicating repulsion.
    • The inhibitory effect is attributed to PNPG acting as a chemo-repellent.

    Conclusions:

    • PNPG acts as a repellent to rat spermatozoa.
    • Spermatozoa repellents, like PNPG, show promise for contraceptive development.

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