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Related Experiment Videos

Disopyramide in pregnancy: a case report.

E J Shaxted, P J Milton

    Current Medical Research and Opinion
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Disopyramide effectively treated maternal arrhythmias during pregnancy. The drug was safe for the fetus, showing no congenital abnormalities or growth issues in the newborn.

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    Area of Science:

    • Cardiology
    • Maternal-Fetal Medicine
    • Pharmacology

    Background:

    • Cardiac arrhythmias like bigeminy and paroxysmal ventricular tachycardia can complicate pregnancy.
    • Management of maternal arrhythmias requires careful consideration of fetal safety.
    • Disopyramide is an antiarrhythmic medication with potential use in pregnancy.

    Observation:

    • A pregnant patient at 26 weeks gestation received disopyramide (200 mg 8-hourly) for recurrent bigeminy and paroxysmal ventricular tachycardia.
    • Labor and delivery proceeded spontaneously and without complications.
    • Disopyramide was detected in fetal blood samples post-delivery.

    Findings:

    • Maternal cardiac arrhythmias were successfully managed with disopyramide.
    • No evidence of congenital abnormalities was observed in the infant.

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  • No signs of fetal growth retardation were noted.
  • The infant showed no apparent adverse effects from prenatal disopyramide exposure.

    • Implications:

    • Disopyramide may be a viable treatment option for specific cardiac arrhythmias in pregnant patients.
    • Further research is warranted to confirm the safety profile of disopyramide during pregnancy.
    • This case suggests a potentially favorable risk-benefit ratio for disopyramide in selected pregnant individuals.