The Zollinger-Ellison syndrome due to an infiltrating tumour of the stomach
- C M Royston , D S Brew , J R Garnham , B H Stagg , J Polak
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View abstract on PubMed
Summary
This summary is machine-generated.This study reports the first Zollinger-Ellison syndrome case caused by a stomach tumor. High plasma gastrin levels and tumor cell gastrin confirmed the diagnosis, indicating a G cell origin.
Area Of Science
- Gastroenterology
- Oncology
- Endocrinology
Background
- Zollinger-Ellison syndrome is characterized by excessive gastric acid secretion.
- Gastrinomas, often in the pancreas or duodenum, are the usual cause.
- Gastric tumors as a source of Zollinger-Ellison syndrome are exceptionally rare.
Purpose Of The Study
- To report the first case of Zollinger-Ellison syndrome originating from a gastric tumor.
- To investigate the cellular origin and hormonal activity of the gastric tumor.
Main Methods
- Clinical case presentation.
- Measurement of plasma gastrin levels.
- Immunofluorescent staining of tumor cells for gastrin.
Main Results
- The patient presented with Zollinger-Ellison syndrome.
- Elevated plasma gastrin levels were detected.
- Gastrin was identified within argyrophil tumor cells in the stomach.
- Evidence suggests the tumor originated from gastric G cells.
Conclusions
- Gastric G cell tumors can cause Zollinger-Ellison syndrome.
- This case expands the known etiology of Zollinger-Ellison syndrome.
- Immunohistochemistry is valuable in diagnosing rare gastrinoma origins.
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