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[Proposal for a method of testing the acute irritative effect of substances by experiments upon animals (author's

H Heise, A Mattheus

    Dermatologische Monatschrift
    |April 1, 1979
    PubMed

    Abstract:

    This paper deals with the test methods for the irritative effect of substances, and suggests a method for standardised determination of acute dermal I.D.50. Liquids or easily soluble substances can be checked in various concentrations with the help of an open application on rabbits.

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