Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

1.9K
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
1.9K
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

764
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
764
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

3.1K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.1K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

693
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
693
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

1.1K
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
1.1K
Histology of the Large Intestine01:26

Histology of the Large Intestine

2.6K
The large intestine, a vital component of the gastrointestinal tract, is structured with four main layers: the mucosa, submucosa, muscularis, and serosa. Each layer performs a distinct role in facilitating the smooth functioning of the large intestine.
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Carcinoma cuniculatum: not a verrucous carcinoma.

Journal of cutaneous pathology·2012
Same author

Focal necrotizing endometritis: a clinicopathologic study of 15 cases.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists·2002
Same author

The stromal component of large endometrial polyps.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists·1999
Same author

Conjunctival melanoma in the black population.

Survey of ophthalmology·1998
Same author

Colonic mucosa in diversion colitis.

Human pathology·1993
Same author

Expression and prognostic significance of estrogen and progesterone receptors in adenocarcinoma of the uterine cervix. An immunocytochemical study.

Cancer·1993
Same journal

TROP2 immunoreactivity in pulmonary large cell neuroendocrine carcinoma.

Histopathology·2026
Same journal

Malignant adenomyoepithelioma of the breast: seven cases illustrating morphological diversity and diagnostic challenges.

Histopathology·2026
Same journal

A CRX-positive RB1-deficient bone tumour with a retinoblastoma-like DNA methylation profile.

Histopathology·2026
Same journal

Perivascular epithelioid cell tumours of the genitourinary tract: clinicopathological features and molecular landscape.

Histopathology·2026
Same journal

Navigating diagnostic challenges in low-grade spindle cell lesions of the breast: a retrospective review.

Histopathology·2026
Same journal

Neoplastic transformation of sporadic gastric hyperplastic polyps: a systematic review and meta-analysis of risk factors and clinicopathological features.

Histopathology·2026
See all related articles

Related Experiment Video

Updated: Dec 23, 2025

Three-dimensional Quantification of Intestinal Mucus Using Whole-mount Tissue Imaging
05:10

Three-dimensional Quantification of Intestinal Mucus Using Whole-mount Tissue Imaging

Published on: September 12, 2025

343

Mucosal hyperplasia in clonic diverticula.

R M Rhatigan, R O Saffos

    Histopathology
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Benign mucosal hyperplasia near colon cancer may not specifically indicate malignancy. This abnormality was frequently found in diverticulosis, suggesting it can occur independently of cancer.

    More Related Videos

    Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
    08:20

    Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

    Published on: July 12, 2018

    13.7K
    Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
    28:15

    Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

    Published on: July 28, 2010

    12.6K

    Related Experiment Videos

    Last Updated: Dec 23, 2025

    Three-dimensional Quantification of Intestinal Mucus Using Whole-mount Tissue Imaging
    05:10

    Three-dimensional Quantification of Intestinal Mucus Using Whole-mount Tissue Imaging

    Published on: September 12, 2025

    343
    Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
    08:20

    Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

    Published on: July 12, 2018

    13.7K
    Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
    28:15

    Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

    Published on: July 28, 2010

    12.6K

    Area of Science:

    • Gastroenterology
    • Colorectal Pathology

    Background:

    • Benign, nonpolypoid mucosal hyperplasia is often observed adjacent to colonic carcinomas.
    • The specificity of this association with malignancy requires further investigation.

    Purpose of the Study:

    • To determine if benign, nonpolypoid mucosal hyperplasia is specifically associated with colonic carcinoma.
    • To investigate the presence of this mucosal abnormality in diverticulosis, a condition not typically linked to cancer.

    Main Methods:

    • Histopathological examination of colonic mucosa.
    • Analysis of mucosal hyperplasia in patients with diverticulosis (with or without diverticulitis).

    Main Results:

    • Nonpolypoid mucosal hyperplasia was frequently identified within diverticula.
    • The findings suggest that this mucosal abnormality is not exclusively linked to malignancy.

    Conclusions:

    • The association between benign, nonpolypoid mucosal hyperplasia and colonic carcinoma may not be as specific as previously thought.
    • This mucosal abnormality can occur in conditions unrelated to cancer, such as diverticulosis.