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Spinal cord blood flow in dogs. 1. The 'normal' flow
Journal of Neurology, Neurosurgery, and Psychiatry
|February 1, 1973
Summary
This study measured canine spinal cord blood flow using a radioactive gas clearance technique. Results showed reproducible white matter blood flow with no significant differences between anesthetic types or spinal cord segments.
Area of Science:
- Neuroscience
- Physiology
Background:
- Accurate measurement of spinal cord blood flow is crucial for understanding neurological conditions.
- Previous methods for assessing spinal cord perfusion have limitations.
Purpose of the Study:
- To establish a reliable method for measuring spinal cord blood flow in vivo.
- To investigate the reproducibility and regional variations of spinal cord white matter blood flow.
- To compare the effects of different anesthetics on spinal cord blood flow.
Main Methods:
- Utilized an inert radioactive gas ((133)Xenon) clearance technique for blood flow measurement.
- Administered (133)Xenon directly into the spinal cord via injection.
- Conducted measurements in anesthetized dogs.
Main Results:
- Demonstrated reproducible blood flow measurements in the spinal cord white matter.
- Observed minimal variation in white matter blood flow across different thoracolumbar segments within the same animal.
- Found no significant differences in spinal cord blood flow among dogs anesthetized with halothane, trichlorethylene, or pentobarbitone.
Conclusions:
- The (133)Xenon clearance technique provides a reliable method for assessing spinal cord white matter blood flow.
- Spinal cord white matter blood flow is consistent across different regions and anesthetic regimens.
- This technique offers a valuable tool for future research into spinal cord perfusion and related pathologies.