Partial inhibition of primary lung tumourigenesis by tetramisole

Continuous treatment of mice with tetramisole (TMS, approximately 8 mg/kg/day) resulted in a highly significant (p < 0.002) reduction in numbers of primary lung tumours forming in response to neonatal urethane injection. Kinetic study indicated the slopes of the oncogenesis response curves differed, but not significantly. Therefore inhibition of primary lung tumourigenesis was only partial, even though TMS was given during the early stages of tumour development, continuously, and at near maximum tolerable dosage.