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Volar melanotic macules.

T A Chapel, R M Taylor, H Pinkus

    International Journal of Dermatology
    |April 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Asymptomatic melanotic macules on palms and soles present as light brown or tannish-gray spots. Histology reveals epidermal hyperpigmentation without increased melanocytes, distinguishing them from other dermatoses.

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    Area of Science:

    • Dermatopathology
    • Dermatology

    Background:

    • Asymptomatic light brown or tannish-gray macules on palms/soles are observed in Black patients and occasionally in White patients.
    • These macules can be misdiagnosed as secondary syphilis or other postinflammatory hyperpigmented dermatoses.

    Purpose of the Study:

    • To histologically characterize volar melanotic macules.
    • To differentiate these macules from other dermatological conditions.

    Main Methods:

    • Histologic examination of 14 necropsy specimens from patients with volar melanotic macules.

    Main Results:

    • Histology showed purely epidermal hyperpigmentation across all epidermal layers.
    • Melanin was observed restricted to large dendritic melanocytes, with minimal transfer to keratinocytes.

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  • Melanocyte count was not significantly increased, and nevus cells were absent in most specimens.

    • Conclusions:

    • Volar melanotic macules exhibit distinct clinical and histological features.
    • These findings aid in differentiating volar melanotic macules from other pigmented skin lesions.
    • Histological analysis confirms epidermal hyperpigmentation as the primary characteristic.