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Related Experiment Videos

Enzyme electrodes.

D A Gough, J D Andrade

    Science (New York, N.Y.)
    |April 27, 1973
    PubMed
    Summary
    This summary is machine-generated.

    Enzyme electrodes offer a feasible method for specific and accurate clinical determinations of metabolites and enzymes. These devices enable continuous monitoring of physiological fluids, potentially minimizing adverse responses for long-term patient observation.

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    Area of Science:

    • Biomedical Engineering
    • Analytical Chemistry
    • Clinical Diagnostics

    Background:

    • Enzyme electrodes are analytical devices utilizing enzymes for detecting specific substances.
    • Current literature suggests the potential of enzyme electrodes in clinical settings.
    • Challenges include specificity, accuracy, and practical application in vivo.

    Purpose of the Study:

    • To evaluate the feasibility of using enzyme electrodes for clinical determinations.
    • To highlight the potential for specificity and accuracy in metabolite and enzyme analysis.
    • To explore the possibility of continuous, long-term clinical monitoring using enzyme electrodes.

    Main Methods:

    • Review of existing literature on enzyme electrodes and their components (electrodes and enzymes).

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  • Discussion of theoretical principles enabling specific and accurate measurements.
  • Consideration of practical aspects for in vivo application.

    • Main Results:

    • Enzyme electrodes demonstrate high specificity through the selection of appropriate enzymes.
    • High accuracy in measurements of metabolites and soluble enzymes is achievable.
    • Continuous and instantaneous determinations from physiological fluids are possible.

    Conclusions:

    • Enzyme electrodes are a feasible technology for clinical determinations of metabolites and enzymes.
    • These devices offer high specificity and accuracy, suitable for clinical applications.
    • Potential for long-term clinical monitoring with minimized physiological response exists.