Cytogenetic investigation of leukemic and preleukemic disorders

Banding chromosome analysis was performed on 35 bone marrow aspirates from patients with various leukemic and nonleukemic hematologic disorders. Of these, 24 had normal karyotypes, while 11 demonstrated various chromosomal abnormalities. Several of the abnormalities have been previously observed and support the concept of nonrandom involvement of specific chromosomes in aberrations associated with hematologic conditions. In addition, some unique abnormalities were demonstrated in three cases: monosomy 1, trisomy 22, and premature chromosome condensation.