Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcitonin secretion in primary hyperparathyroidism.

J G Parthemore, L J Deftos

    The Journal of Clinical Endocrinology and Metabolism
    |August 1, 1979
    PubMed
    Summary

    Primary hyperparathyroidism can increase plasma calcitonin (CT) levels, particularly in males. Females with this condition may have a reduced CT reserve, indicating a sex-based difference in response.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Coherent expression chromosome cluster analysis reveals differential regulatory functions of amino-terminal and distal parathyroid hormone-related protein domains in prostate carcinoma.

    Journal of biomedicine & biotechnology·2006
    Same author

    Treatment of Paget's disease--taming the wild osteoclast.

    The New England journal of medicine·2005
    Same author

    Chondrocyte calcium-sensing receptor expression is up-regulated in early guinea pig knee osteoarthritis and modulates PTHrP, MMP-13, and TIMP-3 expression.

    Osteoarthritis and cartilage·2005
    Same author

    Monitoring of skeletal progression of prostate cancer by GFP imaging, X-ray, and serum OPG and PTHrP.

    The Prostate·2004
    Same author

    Should serum calcitonin be routinely measured in patients with thyroid nodules--will the law answer before endocrinologists do?

    The Journal of clinical endocrinology and metabolism·2004
    Same author

    Parathyroid hormone-related protein regulates the growth of orthotopic human lung tumors in athymic mice.

    Cancer·2001

    Area of Science:

    • Endocrinology
    • Metabolic Bone Disease
    • Hormone Research

    Background:

    • Primary hyperparathyroidism is a common endocrine disorder characterized by excessive parathyroid hormone secretion.
    • Calcitonin (CT) is a hormone involved in calcium homeostasis, primarily produced by the thyroid C-cells.
    • The role of calcitonin in primary hyperparathyroidism, especially concerning sex differences, requires further elucidation.

    Purpose of the Study:

    • To investigate plasma calcitonin levels in patients with primary hyperparathyroidism.
    • To assess the relationship between calcitonin secretion and serum calcium in these patients.
    • To evaluate the impact of parathyroidectomy on calcitonin levels and explore potential sex-specific differences.

    Main Methods:

    • Radioimmunoassay (RIA) was used to measure plasma calcitonin (CT) in 55 patients with primary hyperparathyroidism.
    • Basal hormone levels were measured in all patients; provocative tests were conducted in 7.
    • Biochemical parameters were assessed before and after parathyroidectomy in 34 patients.

    Main Results:

    • Plasma CT levels were significantly elevated in males with primary hyperparathyroidism but not in females.
    • A correlation between plasma CT and serum calcium was observed in males, but not females.
    • Post-parathyroidectomy, male CT levels normalized, while female CT levels showed no significant change.

    Conclusions:

    • Elevated plasma calcitonin in primary hyperparathyroidism may be a compensatory mechanism, particularly in males.
    • Females with primary hyperparathyroidism appear to have a diminished calcitonin secretory capacity, similar to normal females.
    • These findings highlight a sex-specific difference in calcitonin response and reserve in the context of primary hyperparathyroidism.

    Related Experiment Videos