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Related Experiment Videos

Inhibition by oxisuran of cell-mediated hypersensitivity by decrease in numbers of specifically sensitized cells.

A E Fox, J L Gingold, H H Freedman

    Infection and Immunity
    |October 1, 1973
    PubMed
    Summary

    Oxisuran selectively suppresses cell-mediated immunity by reducing the number of sensitized lymphoid cells transferred, without affecting recipient cells. This suggests oxisuran impacts an early event in hypersensitivity responses.

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    Area of Science:

    • Immunology
    • Pharmacology

    Background:

    • Oxisuran (2-([methylsulfinyl]acetyl)pyridine) selectively suppresses cell-mediated immunity.
    • It prolongs allograft survival without inhibiting humoral immunity.

    Purpose of the Study:

    • To investigate oxisuran's effect on lymphoid cell transfer of delayed hypersensitivity.
    • To determine if oxisuran affects sensitized cell donors or recipients.

    Main Methods:

    • Administered oxisuran to actively sensitized animals (mice, rabbits, guinea pigs, rats) before hypersensitivity elicitation.
    • Studied the impact of treating sensitized cell donors versus recipients on hypersensitivity transfer.
    • Quantified specifically sensitized lymphoid cells in passively transferred preparations.

    Main Results:

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    • Oxisuran treatment just before hypersensitivity expression was most inhibitory.
    • Treating sensitized cell donors reduced hypersensitivity in recipients.
    • Fewer specifically sensitized lymphoid cells were found in treated donor preparations, not fewer viable cells.
    • Recipient treatment did not affect hypersensitivity expression.

    Conclusions:

    • Oxisuran appears to inhibit an early, undefined event in the development of cell-mediated hypersensitivity.
    • The compound's mechanism involves impacting the sensitized cells themselves, not the recipient's response.