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Updated: Aug 11, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

Low-pathogenicity variant of lymphocytic choriomeningitis virus

J Hotchin, E Sikora

    Infection and Immunity
    |May 1, 1973
    PubMed

    Insights

    A novel noncytopathic virus was isolated from mouse cells. This virus protects mice against lethal lymphocytic choriomeningitis virus (LCMV) infection.

    Area of Science:

    • Virology
    • Immunology
    • Mouse Models

    Background:

    • Lymphocytic choriomeningitis virus (LCMV) can cause severe disease in mice.
    • Noncytopathic viral strains are valuable tools for studying viral pathogenesis and immunity.

    Purpose of the Study:

    • To isolate and characterize a novel noncytopathic virus from infected mouse cell lines.
    • To evaluate the protective potential of this isolated virus against virulent LCMV challenge.

    Main Methods:

    • Isolation of a noncytopathic virus from LCMV-infected strain L mouse fibroblasts.
    • Assessment of viral pathogenicity in mice.
    • Intracerebral challenge with virulent LCMV to test induced immunity.

    Main Results:

    • A noncytopathic virus was successfully isolated.
    • The isolated virus demonstrated low pathogenicity in mice.
    • Mice infected with the isolated virus were protected from lethal intracerebral LCMV challenge.

    Conclusions:

    • The isolated noncytopathic virus represents a potential candidate for further investigation in viral immunology.
    • This finding suggests a possible mechanism for cross-protection against LCMV infection.

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