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The effect of propranolol on left ventricular function at rest and during exercise in patients with ischemic heart

P Jebavý, J Ressl, R Jandová

    Japanese Heart Journal
    |May 1, 1979
    PubMed

    Insights

    Beta-blocker propranolol reduced left ventricular function and contractility in patients with ischemic heart disease, especially during exercise. Left ventricular filling pressure decreased, highlighting its unreliability for assessing function.

    Area of Science:

    • Cardiology
    • Pharmacology
    • Physiology

    Background:

    • Ischemic heart disease (IHD) poses significant cardiovascular risks.
    • Beta-blockers are commonly used to manage IHD.
    • Assessing left ventricular (LV) function is crucial in IHD management.

    Purpose of the Study:

    • To investigate the effects of beta-blocker propranolol on LV function in patients with IHD.
    • To evaluate LV performance at rest and during exercise before and after propranolol administration.
    • To determine the reliability of LV filling pressure in assessing LV function under propranolol.

    Main Methods:

    • Right and left heart catheterization performed on twelve IHD patients.
    • Hemodynamic parameters assessed at rest and during exercise.
    • Measurements taken before and after propranolol (Inderal) administration.

    Main Results:

    • Propranolol administration led to decreased LV function, particularly significant during exercise.
    • LV contractility was depressed at rest following propranolol.
    • LV filling pressure decreased post-propranolol administration.

    Conclusions:

    • Propranolol negatively impacts LV function and contractility in IHD patients.
    • LV filling pressure alone is an unreliable indicator of LV function in this context.
    • Careful hemodynamic assessment is necessary when evaluating LV function during beta-blocker therapy.

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