[Analysis of ultrastructural myocardial changes in the pathogenesis of post-resuscitation circulatory insufficiency]

The article deals with the electron-microscopic characteristics of morphofunctional changes in the myocardium of dogs resuscitated by means of donor extracorporeal circulation after 13--15 minutes of clinical death caused by an electrical trauma. Damage to the energy and contractile apparatus of the myocytes and structures of the microcirculatory channel was revealed in different postresuscitation periods (in 1, 4--5, 9 hours and in 3 days). The revealed morphofunctional changes were marked by phases. Previous study of changes in the main parameters of hemodynamics in the same animals showed that the hemodynamic shifts occurred in phases; sharp hemodynamic disorders were determined 4 to 5 hours after life had been restored. The authors conclude that the damage to the intracardiac mechanisms responsible for the pump activity of the heart plays an essential role in the genesis of postresuscitation circulatory insufficiency.