Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current trends and problems in health screening.

J M Wilson

    Journal of Clinical Pathology
    |August 1, 1973
    PubMed
    Summary
    This summary is machine-generated.

    Automation in clinical chemistry offers benefits but raises concerns about "normal values" and test significance. Thorough evaluation of screening validity and cost-effectiveness is crucial to avoid diminishing returns and potential harm.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Fission yeast myosin-II isoforms assemble into contractile rings at distinct times during mitosis.

    Current biology : CB·2001
    Same author

    Anteroapical stunning and left ventricular outflow tract obstruction.

    Mayo Clinic proceedings·2001
    Same author

    Congenital diaphragmatic hernia: where are we and where do we go from here?

    Seminars in perinatology·2001
    Same author

    Pulmonary morbidity in 100 survivors of congenital diaphragmatic hernia monitored in a multidisciplinary clinic.

    Journal of pediatric surgery·2001
    Same author

    A quantitative nonimmunogenic transgene product for evaluating vectors in nonhuman primates.

    Molecular therapy : the journal of the American Society of Gene Therapy·2000
    Same author

    Combination therapy with lamivudine and adenovirus causes transient suppression of chronic woodchuck hepatitis virus infections.

    Journal of virology·2000
    Same journal

    Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

    Journal of clinical pathology·2026
    Same journal

    MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

    Journal of clinical pathology·2026
    Same journal

    Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

    Journal of clinical pathology·2026
    Same journal

    MRI-targeted versus systematic needle core biopsies in prostate cancer: a patient-based analysis of potential diagnostic and biologic underestimation.

    Journal of clinical pathology·2026
    Same journal

    Basal plasmacytosis and eosinophilia for distinguishing inflammatory bowel disease from gastrointestinal tuberculosis on mucosal biopsy.

    Journal of clinical pathology·2026
    Same journal

    Assay-dependent variability in free thyroxine (FT4): differential interference related to immunoassay design in a patient with subclinical hypothyroidism.

    Journal of clinical pathology·2026
    See all related articles

    Area of Science:

    • Clinical Chemistry
    • Laboratory Medicine
    • Diagnostic Testing

    Background:

    • Automation in clinical chemistry presents both opportunities and challenges.
    • The widespread use of automated laboratory testing prompts re-evaluation of traditional diagnostic approaches.

    Purpose of the Study:

    • To examine the impact of automation on clinical chemistry practices.
    • To assess the validity and cost-effectiveness of automated population screening methods.

    Main Methods:

    • Review of existing literature on automation in clinical chemistry.
    • Analysis of population screening data and intervention studies.
    • Cost-effectiveness analysis of laboratory testing.

    Main Results:

    Related Experiment Videos

    • Automation necessitates a redefinition of "normal values" and improved methods for interpreting laboratory test significance.
    • The ease and low cost of automated screening can lead to over-utilization, potentially resulting in diminishing returns and patient inconvenience or harm.
    • Rigorous examination of the clinical utility of numerous laboratory tests is ongoing.

    Conclusions:

    • The clinical value of laboratory tests requires continuous scrutiny, especially with increasing automation.
    • Population surveys and intervention studies are essential to validate novel screening strategies in clinical chemistry.
    • The overall cost-effectiveness of screening must be considered beyond the mere cost of individual tests.