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Cardiovascular function in anesthetized miniature swine.

N M Buckley, P M Gootman, P Brazeau

Laboratory Animal Science

|April 1, 1979

Summary

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Cardiovascular responses in miniature swine to catecholamines, baroreceptor inhibition, and vagal nerve stimulation were investigated. Findings reveal similarities to other mammals, with strain-specific femoral resistance changes observed.

Area of Science:

Cardiovascular Physiology
Mammalian Physiology

Background:

Miniature swine are increasingly used as models for human cardiovascular research.
Understanding their autonomic nervous system control is crucial for translational studies.

Purpose of the Study:

To characterize the cardiovascular function of miniature swine.
To investigate responses to autonomic stimuli including catecholamines, baroreceptor modulation, and vagal nerve activity.

Main Methods:

Anesthetized miniature swine underwent comprehensive cardiovascular monitoring.
Hemodynamic parameters (aortic pressure, heart rate, blood flow, resistance) were measured.
Responses to norepinephrine, epinephrine, isoproterenol, baroreceptor inhibition, and vagal stimulation were assessed.

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Main Results:

Catecholamine effects mirrored those in other mammals, with adrenergic receptor blockade confirming mechanisms.
Carotid baroreceptor inhibition caused hypertension, bradycardia, and increased peripheral resistance.
Bilateral vagotomy resulted in hypertension and tachycardia, with notable strain differences in femoral resistance.
Vagal nerve stimulation induced bradycardia without hypotension.

Conclusions:

Miniature swine exhibit mammalian-like cardiovascular responses to autonomic stimuli.
Adrenergic and vagal mechanisms are conserved, but strain-specific variations in vascular resistance exist.
This study provides valuable data for using swine as cardiovascular research models.