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A natural outbreak of transmissible murine colonic hyperplasia in A/J mice
Abstract:
Transmissible murine colonic hyperplasia was diagnosed in 6-month-old A/J mice kept under standard laboratory conditions. Bacterial cultures revealed the presence of Citrobacter freundii (4280). Clinical signs included rough coats, feces adhering to the anus, slight dehydration and rectal prolapses. A nonclotting sanquinous intestinal fluid and gross colonic thickening were frequently seen at necropsy. Morbidity was approximately 50%; mortality approximately 25%. Tetracycline appeared to be effective in controlling the disease.
Insights
Transmissible murine colonic hyperplasia, caused by Citrobacter freundii, affected A/J mice. Tetracycline treatment effectively controlled this bacterial infection and its associated clinical signs.
Area of Science:
- Veterinary Pathology
- Microbiology
- Animal Models
Background:
- Murine models are crucial for understanding gastrointestinal diseases.
- Citrobacter freundii is an opportunistic pathogen that can cause infections in various hosts.
Observation:
- A transmissible colonic hyperplasia outbreak occurred in 6-month-old A/J mice.
- Clinical signs included rough coats, fecal soiling, dehydration, and rectal prolapse.
Findings:
- Bacterial cultures confirmed Citrobacter freundii as the causative agent.
- Necropsy revealed non-clotting intestinal fluid and colonic thickening.
- Morbidity reached approximately 50% with a 25% mortality rate.
Implications:
- This study highlights Citrobacter freundii as a significant pathogen in laboratory mice.
- Effective control was achieved with tetracycline, offering a treatment strategy.
- Understanding this condition is vital for maintaining the health of research animal colonies.